Longevity Insights
Peer-reviewed research translated into actionable intelligence. Browse by category or scroll for the latest.
Visceral fat vs BMI: which better predicts heart disease?
Visceral fat vs BMI as a heart risk predictor: waist based measures tracked events steadily, while a normal BMI did not rule out excess organ fat.
Does PRP work for hair loss? Some regrowth, inconsistent evidence
PRP injections use your own blood to try to treat hair loss. In pattern baldness the evidence shows modest regrowth, no standard protocol, and no cure.
What does a coronary calcium score mean? A zero is the clearest answer
A coronary calcium score counts hardened plaque in the heart arteries. In one review, people with none had about a 1% chance of an event over 10 years.
Does a cold plunge help with muscle recovery? Soreness yes, strength no
A cold plunge helps muscle recovery in one sense: soreness drops, while repeated use after lifting appears to blunt strength and muscle-size gains.
Does red light therapy work for wrinkles? One trial used a dummy mask
Does red light therapy work for wrinkles? In a 16-week trial, 60 adults used a light mask or an identical dummy - raters saw the difference.
How do you reset your circadian rhythm? A trial shifted night owls by 2 hours
What resets your circadian rhythm is when light reaches your eyes, not how much you get: morning light pulls the clock earlier, evening light pushes it later.
Are executive health check-ups worth it? The trials tested a simpler check
Executive health check-ups bundle dozens of tests. The randomised evidence covers a plainer version, and across 233,298 adults it did not move the death rate.
How accurate is Apple Watch VO2 max? About 6 points below a lab test
Apple Watch VO2 max accuracy, measured against lab equipment in 30 adults: the watch read about 6 points low, and single readings missed by more.
Do growth hormone peptides work? The trials stop before ageing
Sermorelin, ipamorelin and CJC-1295 do raise growth hormone. Reviews of the ageing growth hormone axis stop short of recommending growth hormone peptides.
Is creatine safe for teenagers? The evidence is thin, not alarming
Studies in teenage athletes have not recorded adverse events, but whether creatine is safe for teenagers rests on a few small, short trials.
Is ApoB better than LDL cholesterol for predicting heart disease?
ApoB out-predicted LDL cholesterol in all nine head-to-head studies in a review of 593,354 adults, but it still understates Lp(a) and remnant risk.
Is testosterone therapy safe long term? The evidence runs about three years
The largest heart-safety trial treated men for roughly two years. Whether testosterone therapy is safe long term rests on one study that disagrees.
Does IV vitamin therapy work? The trials were run on hospital patients
The serious trials of IV vitamin therapy tested people already in hospital, not healthy adults, and the largest found no benefit.
When is the best time to take creatine? The daily total matters more
The best time to take creatine is whenever you will take it consistently: one 32-week trial in adults over 50 put after-training slightly ahead of before.
Does rapamycin slow aging in humans? What three trials measured
Does rapamycin slow aging? No human trial has measured lifespan. The three that exist looked at flu antibodies, skin cells and one year of safety.
What GLP-1 drugs do beyond weight loss
GLP-1 drugs act beyond weight loss, most clearly in the heart and kidneys of people with type 2 diabetes or obesity; brain and mood evidence is still early.
Do senolytics work? In humans, one 9-person trial cleared senescent cells
Do senolytics work? In mice they ease dozens of conditions. In people, one nine-person trial removed worn-out cells, and no trial has tested ageing itself.
Is TRT a lifelong treatment? It depends on why testosterone is low
Whether TRT is a lifelong treatment depends on the cause of the low testosterone - permanent damage to the glands, or obesity, which can be reversible.
Does whole-body cryotherapy work? The evidence is strongest for pain
Whole-body cryotherapy lowered pain in five studies of 310 people with spinal arthritis, but changed no recovery marker in trained athletes.
How to improve your VO2 max: about 5 points, intervals or steady
Controlled trials in 723 healthy adults: intervals and steady endurance each improve your VO2 max by about 5 points. Intensity decides the size.
Does stem cell therapy work for knees? Modest relief, uncertain repair
A Cochrane review of 25 randomised trials found stem cell therapy eased knee pain slightly, and that not one trial checked whether cartilage changed.
What is a good VO2 max for a man by age? The bands from 15 to 74
A good VO2 max for a man by age, set out as five graded bands from 2,837 Brazilian treadmill tests, so you can place your own score at any decade.
What are the side effects of NAD+ IV therapy? The evidence is oral
NAD+ IV therapy side effects have not been catalogued in a trial. Those on record, muscle pain, tiredness and headaches, come from 489 people on NADH pills.
Does red light therapy work for hair loss?
Red light therapy grows measurably more hair than a dummy device in pattern hair loss, but the trials are small and rarely test the machines clinics sell.