Ageing insights
Peer-reviewed ageing research, translated into plain English.
What are the side effects of low-dose rapamycin? No more than a placebo
Over 48 weeks in healthy adults, side effects of low-dose rapamycin matched a dummy pill. The heavier list comes from daily transplant doses.
How accurate is a DEXA scan for body fat?
How accurate is a DEXA scan for body fat? It is the reference clinics measure against, not a true gold standard, and the method gaps are large.
Does calorie restriction slow aging? What the CALERIE trial found
The one long trial of calorie restriction in healthy adults slowed a single measure of aging - and people ate 12% less, not the 25% asked of them.
Does rapamycin slow aging in humans? What three trials measured
Does rapamycin slow aging? No human trial has measured lifespan. The three that exist looked at flu antibodies, skin cells and one year of safety.
Do senolytics work? In humans, one 9-person trial cleared senescent cells
Do senolytics work? In mice they ease dozens of conditions. In people, one nine-person trial removed worn-out cells, and no trial has tested ageing itself.
What are the side effects of NAD+ IV therapy? The evidence is oral
NAD+ IV therapy side effects have not been catalogued in a trial. Those on record, muscle pain, tiredness and headaches, come from 489 people on NADH pills.
What does a DEXA scan show, and is it worth the money?
What a DEXA scan shows - bone density, body fat, lean mass, visceral fat - and which of those four numbers the evidence says is worth paying for.
Does NAD+ IV therapy work? The evidence is one heart failure trial
Clinics sell NAD+ IV therapy for energy and ageing. The one randomised trial of the infusion gave it to 180 people with heart failure, for seven days.
Are biological age tests accurate? The number depends on the clock
Biological age tests get your real age right. Whether the gap they sell you survives a second test depends on which clock the laboratory ran.