Does red light therapy work for wrinkles? One trial used a dummy mask
Does red light therapy work for wrinkles? In a 16-week trial, 60 adults used a light mask or an identical dummy - raters saw the difference.
Educational, not medical advice. Always consult a qualified healthcare provider before changing your diet, supplements, or routine. Full disclaimer.
Recommendation
Red light therapy reduces the appearance of crow's feet, the fine lines that fan out from the outer corner of the eye, in the one facial trial that tested it against an identical dummy device [13]. In that 16-week study of 60 adults aged 30 to 65, independent assessors rated 86.2% of the light-mask group as improved, an improvement rate 69.5 points ahead of the dummy group [13]. The other studies on faces are smaller and had nobody to compare against, and none of this research tested the panels and masks sold for home use, whose light output has never been checked against the devices in the papers they cite [15].
The findings
Does red light therapy work for wrinkles? Around the eyes, yes, on the strength of one trial built to rule out wishful thinking [13]. Red light therapy, called photobiomodulation in the research, means shining red light onto the skin at wavelengths of roughly 620 to 700 nanometres, or the invisible near-infrared light just beyond it, from a lamp, panel or mask [9]. Nanometres measure the colour of light: visible red sits at the long end of what the eye can pick up.
The trial that carries the most weight ran 16 weeks across two centres [13]. Sixty adults of Asian descent, aged 30 to 65 and all with visible crow's feet, were given either a mask combining 630-nanometre red light with 850-nanometre infrared, or a dummy mask that looked and felt the same but emitted nothing. Neither the participants nor the people scoring their faces knew who had the working device.
Independent assessors rated 86.2% of the light-mask group as improved, an improvement rate 69.5 points ahead of the dummy group [13]. The two groups had separated by week 8 and were still apart at weeks 12 and 16 [13]. Nobody reported pain, and the researchers recorded no tolerance problems [13].
Skin firmness and tightening have been measured too, but with nobody to compare against. Twenty healthy women used a red light mask at 630 nanometres for 12 minutes, twice a week for three months [8]. Researchers tracked the depth of their crow's feet, how firm and stretchy the skin was, the density of the dermis - the thick layer beneath the surface - by ultrasound, plus cheek roughness, pore size and evenness of skin tone. Improvements built month by month, every volunteer said their skin looked better overall, and the changes were still there a month after the last session [8]. Everyone in that study used the mask, so what three months of twice-weekly attention to your own face does on its own remains unknown.
The single study in men ran six weeks on a mask mixing 633, 830 and 1072 nanometres, and leaned on what participants said about themselves alongside computer analysis of photographs [12]. Wrinkles, brown spots and pores all scored better. No comparison group there either.
What you can buy is not what was tested. A 2026 analysis of 132 social media posts promoting at-home red light devices, with a potential audience of 47.5 million followers, found that only 8.3% pointed to a peer-reviewed paper, and that the energy output of the promoted devices has never been measured against the specifications in the studies being invoked [15]. Skin was the benefit named in 88.6% of the posts, and 64.4% came from people with no health credentials [15].
Why it works
Red light is absorbed inside the cell. Its main receiver is cytochrome c oxidase, part of the machinery inside mitochondria, the compartments that turn food and oxygen into a cell's usable energy; red and near-infrared light also reach light-sensitive proteins in skin called opsins [10]. Shift what mitochondria are doing and you shift what the cell does next, which is why one light source ends up offered for skin problems that have little to do with each other [10].
In skin, the relevant cells are fibroblasts, which manufacture collagen, the protein that gives skin its structure. In naturally ageing mice, red light thickened the deeper layer of skin: it pushed fibroblasts to make more type I collagen and damped down the enzymes that break collagen apart [2]. That was mouse skin.
Dose decides the direction, and this is the part the advertising leaves out. In human skin fibroblasts grown in a dish, high-dose red light did the reverse. It cut levels of TGF-beta 1, the signal that tells fibroblasts to lay down collagen, to 59% and 54% of untreated cells at two different doses [4]. Researchers are pursuing that effect deliberately, as a way to calm conditions where the body deposits too much collagen, such as raised keloid scars [6].
Limitations
The strongest evidence here is one trial of 60 people [13]. It enrolled adults of Asian descent with Fitzpatrick skin types II to V, a scale of how skin reacts to sun that runs from skin which burns easily to skin which rarely burns, and everyone in it already had visible crow's feet and wanted them treated [13]. It measured one wrinkle, beside the eye, over 16 weeks.
The evidence does not cover:
- anyone under 30 or over 65, who fell outside that trial's age range [13]
- the deeper folds and loose skin people usually mean when they talk about tightening, since nothing here measured them
- full-body light panels and beds, because every facial study used a mask or an array pointed at the face [8] [12] [13]
- what happens more than a month after the sessions stop [8]
- skin disease, which is a separate question from how skin looks
Two of the three facial studies had no control group [8] [12], and one leaned on participants scoring themselves [12]. That matters more than usual, because everyone involved knew they were being treated and skin appearance is judged by eye.
Reviews in dermatology journals land in the same place. The treatment is non-invasive and looks safe, and the trials vary so much in wavelength, dose and timing that no standard protocol exists to point anyone at [9] [10].
Real-world example
Longevity clinics and aesthetic practices commonly list red light therapy, sometimes sold as LED therapy or photobiomodulation, and the Longevinsights clinic directory carries it as a service you can filter for. The research gives a rough shape of what a course looks like: short sessions, repeated, over months rather than weeks. The trial with the dummy device ran 16 weeks [13], the women's mask study used 12 minutes twice a week for three months [8], and the men's study ran six weeks [12]. A single visit is not what any of these papers tested.
That makes the machine worth asking about: which wavelengths it emits, how much energy it delivers to the skin, and how many sessions a course runs. The studies that found an effect on wrinkles used light aimed at the face at particular wavelengths, 630 and 850 nanometres in the trial with the dummy device [13]. Dermatology reviews ask clinicians to set expectations honestly for people using these devices, especially at home [9].
Primary paper
Clinical study to evaluate the efficacy and safety of home-used LED and IRED mask for crow's feet: A multi-center, randomized, double-blind, sham-controlled study.
Park SH, et al.
Medicine, 2025
View paper on publisher websiteSources
Numbers in brackets [1], [2]… in the body link to this list.
- [1]
The Asian dermatologic patient: review of common pigmentary disorders and cutaneous diseases.
Ho SG, Chan HH · American journal of clinical dermatology · 2009
doi.org/10.2165/00128071-200910030-00002 - [2]
Red light promotes dermis-epidermis remodeling via TGFβ and AKT-mediated collagen dynamics in naturally aging mice.
Chang H, Shen Q, Tan Y, et al. · Zoological research · 2025
doi.org/10.24272/j.issn.2095-8137.2024.405 - [3]
MicroRNA expression analysis of human skin fibroblasts treated with high-fluence light-emitting diode-red light.
Mamalis A, Koo E, Tepper C, et al. · Journal of biophotonics · 2019
doi.org/10.1002/jbio.201800207 - [4]
High-Fluence Light-Emitting Diode-Generated Red Light Modulates the Transforming Growth Factor-Beta Pathway in Human Skin Fibroblasts.
Mamalis A, Jagdeo J · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2018
doi.org/10.1097/DSS.0000000000001549 - [5]
The Combination of Resveratrol and High-Fluence Light Emitting Diode-Red Light Produces Synergistic Photobotanical Inhibition of Fibroblast Proliferation and Collagen Synthesis: A Novel Treatment for Skin Fibrosis.
Mamalis A, Jagdeo J · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2017
doi.org/10.1097/DSS.0000000000000921 - [6]
Photobiomodulation therapy in keloid management: a comprehensive review.
Prananda AT, Syahputra RA · Frontiers in medicine · 2025
doi.org/10.3389/fmed.2025.1550662 - [7]
Influence of 5-aminolevulinic acid and red light on collagen metabolism of human dermal fibroblasts.
Karrer S, Bosserhoff AK, Weiderer P, et al. · The Journal of investigative dermatology · 2003
doi.org/10.1046/j.1523-1747.2003.12037.x - [8]
Reverse skin aging signs by red light photobiomodulation.
Couturaud V, Le Fur M, Pelletier M, et al. · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
doi.org/10.1111/srt.13391 - [9]
Photobiomodulation CME part II: Clinical applications in dermatology.
Mineroff J, Maghfour J, Ozog DM, et al. · Journal of the American Academy of Dermatology · 2024
doi.org/10.1016/j.jaad.2023.10.074 - [10]
The Application of Light Emitting Diode (LED) in Cosmetic Dermatology.
Guo Z, Yuan K · Photodermatology, photoimmunology & photomedicine · 2025
doi.org/10.1111/phpp.70041 - [11]
Editorial.
Goldberg DJ · Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2017
doi.org/10.1080/14764172.2017.1313515 - [12]
Male facial rejuvenation using a combination 633, 830, and 1072 nm LED face mask.
Mineroff J, Austin E, Feit E, et al. · Archives of dermatological research · 2023
doi.org/10.1007/s00403-023-02663-w - [13]
Clinical study to evaluate the efficacy and safety of home-used LED and IRED mask for crow's feet: A multi-center, randomized, double-blind, sham-controlled study.
Park SH, Park SO, Jung JA · Medicine · 2025
doi.org/10.1097/MD.0000000000041596 - [14]
Photodynamic therapy: a review.
McCaughan JS · Drugs & aging · 1999
doi.org/10.2165/00002512-199915010-00005 - [15]
At-Home Red Light Therapy Devices: Promotion and Recommendation Patterns on Social Media in the Context of Limited Evidence.
Merkle T, Tomczak L, Do K, et al. · Cureus · 2026
doi.org/10.7759/cureus.103274